Sevilla became surprise Liga leaders on Sunday after beating visiting Celta Viga 2-1 while champions Barcelona drew 1-1 at Valencia thanks to another Lionel Messi strike but are still without a victory in their last four league games.
France forward Antoine Griezmann says he would only leave Atletico Madrid if manager Diego Simeone also quit the La Liga club.
Here are five talking points from the weekend in La Liga.
Ten-man Premier League leaders Leicester City lost at title-chasing Arsenal, while La Liga pacesetters Barcelona crushed Celta Vigo and Juventus took over from Napoli at the top of Serie A by edging their rivals.
United's leading goal-scorer suffered knee ligament damage during the 2-1 Europa League quarter-final win over Anderlecht last month and has been ruled out for the rest of the season.
Barcelona were in danger of being toppled from the top of La Liga standings on Sunday after they suffered a shock 2-1 defeat at Deportivo La Coruna.
Real Madrid romped to a 4-1 win at tiny Eibar on Saturday, provisionally returning to the top of La Liga, despite the absence of Gareth Bale and Cristiano Ronaldo for Zinedine Zidane's side.
La Liga champions Barcelona stayed on the heels of leaders Real Madrid by coasting to a 3-0 home win over Athletic Bilbao on Saturday as Lionel Messi became the club's top scorer from free kicks.
Having won eight of the past 12 league titles coming into this campaign, where has it gone so wrong for Barcelona?
The 48-year-old Argentine saw his side produce a stirring fight back from three goals down to draw 3-3 with Liverpool in the Champions League on Tuesday and Spanish media reported that he told his players about the illness at half-time.
Real Madrid did not specify if he would be out of action for any length of time
Morata, who had scored his first goal for the club in last week's 2-0 win over Villarreal, rose to head home from close range on the half-hour mark following a corner which had been flicked on by Atleti captain Diego Godin.
Barcelona's 100 per cent start to the season was ended by Catalonian neighbours Girona, who picked up a draw at the Nou Camp, allowing Real Madrid to take advantage with a victory over Espanyol.
Real Madrid crashed out of the King's Cup quarter-finals 4-3 on aggregate after being held to a 2-2 draw at Celta Vigo on Wednesday in another major setback for the stuttering European champions.
Antoine Griezmann and Yannick Carrasco each conjured moments of magic as Atletico Madrid recaptured top spot in La Liga from Barcelona with a hard-fought 2-0 victory at Celta Vigo on Sunday.
Celta Vigo thrashed Barcelona 4-1 on Wednesday with Iago Aspas hitting a double.
Barcelona lost for the second straight La Liga game in a 1-0 home reverse against Celta Vigo but there was no such trouble for Manchester City, who beat 10-man Manchester United 1-0 thanks to Sergio Aguero.
La Liga leaders Barcelona drew 0-0 at Huesca on Saturday and are nine points clear of second-placed Atletico Madrid, who cut the gap by beating Celta Vigo 2-0.
The draw means second-placed Atletico Madrid could close the 12-point gap with Barcelona, who are on 74 points, if they beat Celta Vigo later on Saturday.
Lionel Messi netted his first hat-trick in 10 months as Barcelona swept aside struggling Granada 4-0 to climb above Atletico Madrid to the top of La Liga on Saturday.
Here are five talking points from the weekend's action:
Real Madrid have exonerated Argentina winger Angel Di Maria over an incident in Monday's La Liga game at home to Celta Vigo when he was caught on camera grabbing his crotch while being substituted.
Barcelona drew 1-1 at Valencia after Real Madrid lost 1-0 away to Alaves, allowing Sevilla to go top of La Liga with a 2-1 home win over Celta Vigo on Sunday. Here are five talking points from the weekend's La Liga action.
All the action from football matches played in Europe on Wednesday
Following public comments from La Liga chief Javier Tebas, who said it was "not ideal" for the second El Clasico meeting between Real and Barca last season to be played with the latter having already won the league title, the two sides will face off earlier this campaign.
News of all that's transpired on and off the football field.
Lionel Messi scored yet another hat-trick and surpassed 400club goals as Barcelona came from behind to win the Catalan derby 5-1 against Espanyol.
Barcelona said on Saturday they had named former midfielder and captain Xavi Hernandez as head coach on a contract until 2024, following the sacking of Ronald Koeman.
Atletico Madrid fell to their heaviest league defeat of the season
Manchester United should be "embarrassed" at trailing Premier League leaders Chelsea by 19 points and Jose Mourinho's first year in charge will not be considered a success even if they win the Europa League, former skipper Roy Keane said.
Portugal international Goncalo Guedes fired Valencia into the lead in the 35th minute with a thumping shot from inside the area which was too powerful for Madrid goalkeeper Keylor Navas.
Jaume Costa atoned for giving away a first-half penalty when his strike five minutes from time rescued Villarreal a 1-1 draw against Eibar that put them fourth in La Liga on Sunday.
Villarreal went top with a 1-0 win over Atletico Madrid on Saturday after a toothless Real Madrid were held 0-0 at home to 10-man Malaga and Lionel Messi suffered a serious injury as Barcelona beat Las Palmas 2-1.
European football was given good and bad reminders of its past on Thursday with an impressive 2-0 win for once-mighty Ajax Amsterdam over Schalke 04 in one Europa League game but ugly scenes in the crowd at Lyon delaying another.
Robert Lewandowski and Raphinha both scored twice to help Barcelona thrash hosts Villarreal 5-1.
Premier League-based trio Diego Costa, Juan Mata and Santi Cazorla were among a high-profile list of absentees when Spain coach Vicente Del Bosque named his provisional 25-man squad for Euro 2016 on Tuesday. Costa injured his hamstring against Liverpool in Chelsea's penultimate game of the season. Atletico Madrid striker Fernando Torres was also absent from the squad despite his improved form towards the end of the season, as were Arsenal midfielder Cazorla and Valencia forward Paco Alcacer, Spain's top scorer in their qualifying campaign.
Valencia climbed above Atletico Madrid and Sevilla into third in La Liga when Alvaro Negredo came off the bench to score a late winner in a 3-2 home victory over his former club Almeria on Saturday.
Manchester United's teenage striker Marcus Rashford struck a stunning second-half free-kick to secure a 1-0 win at Celta Vigo in their Europa League semi-final, first leg on Thursday.
Real Madrid coach Zinedine Zidane has opened the door to out-of-favour midfielder James Rodriguez leaving the club by admitting the player's lack of appearances could become a problem.
La Liga leaders Barcelona hit two goals in the final three minutes to earn a 3-2 win at Rayo Vallecano
